Konstantinos Liatsikos

Oct 26, 2023 | nature.com | Elena Mitsi |Konstantinos Liatsikos |josh Hamilton |Teresa Lambe |Simon Draper |Alessandro Sette | +1 more

AbstractRespiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, the capacity of peripheral vaccination to generate sustained immunity in the lung mucosa, and how this is influenced by prior SARS-CoV-2 infection, is unknown. Here we show using bronchoalveolar lavage samples that donors with history of both infection and vaccination have more airway mucosal SARS-CoV-2 antibodies and memory B cells than those only vaccinated.