Alessandro Sette

May 13, 2024 | nature.com | Alexander J. Mentzer |Martin Pollard |Deepti Gurdasani |Amanda Chong |Rasmus Nielsen |Nicolas Timpson | +10 more

AbstractHow human genetic variation contributes to vaccine effectiveness in infants is unclear, and data are limited on these relationships in populations with African ancestries. We undertook genetic analyses of vaccine antibody responses in infants from Uganda (n = 1391), Burkina Faso (n = 353) and South Africa (n = 755), identifying associations between human leukocyte antigen (HLA) and antibody response for five of eight tested antigens spanning pertussis, diphtheria and hepatitis B vaccines.

Oct 26, 2023 | nature.com | Elena Mitsi |Konstantinos Liatsikos |josh Hamilton |Teresa Lambe |Simon Draper |Alessandro Sette | +1 more

AbstractRespiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, the capacity of peripheral vaccination to generate sustained immunity in the lung mucosa, and how this is influenced by prior SARS-CoV-2 infection, is unknown. Here we show using bronchoalveolar lavage samples that donors with history of both infection and vaccination have more airway mucosal SARS-CoV-2 antibodies and memory B cells than those only vaccinated.

Jun 22, 2023 | mdpi.com | Linda Petrone |Alessandro Sette |Delia Goletti |de Vries

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReviewbyLinda Petrone 1, Alessandro Sette 2,3, Rory D.