Kris Strunge

Sep 18, 2023 | nature.com | Steven J. Roeters |Kris Strunge |Yuge Zhang |Mingdong Dong |Daniel Otzen |Birgit Schiøtt | +2 more

AbstractThe amyloid aggregation of α-synuclein (αS), related to Parkinson’s disease, can be catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and orientation of lipid-bound αS is still not known in detail. Here, we report interface-specific vibrational sum-frequency generation (VSFG) experiments that reveal how monomeric αS binds to an anionic lipid interface over a large range of αS-lipid ratios.