Kristian Franze

Oct 29, 2024 | nature.com | Kristian Franze

Spring-like force sensors bioprinted in the developing neural tube of growing chick embryos enable the measurement of forces generated by embryonic tissues with micrometre-level resolution.

Jul 3, 2024 | jneurosci.org | Kristian Franze |Julie Qiaojin Lin |Christine E. Holt

Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development Francesca W. van Tartwijk, Lucia C. S. Wunderlich, Ioanna Mela, Stanislaw Makarchuk, Maximilian A. H. Jakobs, Seema Qamar, Kristian Franze, Gabriele S. Kaminski Schierle, Peter H. St George-Hyslop, Julie Qiaojin Lin, Christine E. Holt, Clemens F. Kaminski Journal of Neuroscience 3 July 2024, 44 (27) e2148232024; DOI: 10.1523/JNEUROSCI.2148-23.2024

Apr 30, 2024 | jneurosci.org | Kristian Franze |Julie Qiaojin Lin |Christine E. Holt

AbstractAberrant condensation and localisation of the RNA-binding protein (RBP) fused in sarcoma (FUS) occur in variants of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Changes in RBP function are commonly associated with changes in axonal cytoskeletal organisation and branching in neurodevelopmental disorders. Here, we asked whether branching defects also occur in vivo in a model of FUS-associated disease.