Kristin Tsuo

Jan 24, 2025 | digitalcommons.library.tmc.edu | Lerato Majara |Allan Kalungi |Nastassja Koen |Kristin Tsuo

KeywordsHumans, Genetic Predisposition to Disease, Genome-Wide Association Study, Multifactorial Inheritance, Uganda, Polymorphism, Single Nucleotide, polygenic scores, Africa, GWAS, health disparities, global health, population geneticsAbstractAfrican populations are vastly underrepresented in genetic studies but have the most genetic variation and face wide-ranging environmental exposures globally.

Sep 14, 2023 | cell.com | Kristin Tsuo |Kai Yuan |Transdisciplinary Research Initiatives

PRSmulti usually improves predictive performance compared with PRSsingleWe constructed PRSsingle using P + T and PRS-continuous shrinkage (PRS-CS) with GWASs from the UKBB and the BBJ, respectively. The GWAS sample sizes varied based on the number of BinTotal, which represented the total number of bins specific to each trait as shown in Table S3. Each bin consisted of 5,000 individuals randomly selected from the respective cohort.