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Nov 7, 2024 | 
molecular-cancer.biomedcentral.com | Transdisciplinary Research Initiatives |Japan Agency
This study was conducted on individuals who underwent colonoscopy at the National Cancer Center Hospital (NCCH), Tokyo, Japan, and the National Cancer Center Hospital East (NCCHE), Chiba, Japan.
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Sep 17, 2024 | 
link.springer.com | Transdisciplinary Research Initiatives |Japan Agency
AbstractInflammatory respiratory diseases, such as interstitial lung disease (ILD), bronchial asthma (BA), chronic obstructive pulmonary disease (COPD), and respiratory infections, remain significant global health concerns owing to their chronic and severe nature. Emerging as a valuable resource, blood extracellular vesicles (EVs) offer insights into disease pathophysiology and biomarker discovery in these conditions.
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Sep 10, 2024 | 
academic.oup.com | Transdisciplinary Research Initiatives
Meta-analysis is a powerful tool to synthesize findings from multiple studies. The normal–normal random-effects model is widely used to account for between-study heterogeneity. However, meta-analyses of sparse data, which may arise when the event rate is low for binary or count outcomes, pose a challenge to the normal–normal random-effects model in the accuracy and stability in inference since the normal approximation in the within-study model may not be good.
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Sep 3, 2024 | 
academic.oup.com | Transdisciplinary Research Initiatives
The summary receiver operating characteristic (SROC) curve has been recommended as one important meta-analytical summary to represent the accuracy of a diagnostic test in the presence of heterogeneous cutoff values. However, selective publication of diagnostic studies for meta-analysis can induce publication bias (PB) on the estimate of the SROC curve.
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Aug 23, 2024 | 01028-3&sz=64)
cell.com | Yoshiaki Yasumizu |Transdisciplinary Research Initiatives |Makoto Kinoshita |Martin Zhang
Highlights•Spatial transcriptomics reveals MG-specific features in the thymus•Multimodal data integration highlights disease association in the medulla•We identify specific immune niches in the medulla and nmTEC enrichment in the junctionSummaryMyasthenia gravis (MG) is etiologically associated with thymus abnormalities, but its pathology in the thymus remains unclear.
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May 9, 2024 | 
link.springer.com | Transdisciplinary Research Initiatives
AbstractChildbirth is a stressful event for mothers, and labor epidural analgesia (LEA) may reduce mental stress. Mental stressors include labor pain, fear, and anxiety, which induce oxidative stress. In this study, we focused on oxidative stress during delivery and conducted a cross-sectional analysis of maternal and fetal oxidative stress. The participants included 15 women who received LEA (LEA group) and 15 who did not (No LEA group).
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Apr 15, 2024 | 
academic.oup.com | Transdisciplinary Research Initiatives
Oligonucleotide therapeutics, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), have been shown to directly regulate protein expression (1), which is not feasible with small-molecule drugs and antibodies. Given their unique mechanisms in controlling the production of disease-related proteins via the regulation of gene expression (2), oligonucleotide therapeutics could be applied to various genetic diseases (3).
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Feb 14, 2024 | 
karger.com | Transdisciplinary Research Initiatives
Keywords:
Recurrent macular hole,
Gas tamponade,
Retinal detachment,
Case report
The pathology of full-thickness macular holes (FTMHs) has been extensively studied, and both vertical and horizontal traction by the vitreous and epiretinal membranes have been recognized as contributing factors [1‒3]. Kelly and Wendel [4] pioneered the treatment of FTMH using pars plana vitrectomy and gas tamponade.
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Feb 5, 2024 | 
karger.com | Transdisciplinary Research Initiatives
Introduction: In transbronchial biopsy of peripheral pulmonary lesions, the bronchoscope can reach only a limited depth due to the progressive narrowing of bronchi, which may reduce the diagnostic rate. This study examined the balloon dilatation for bronchoscope delivery (BDBD) technique, employing a novel balloon device to enhance bronchoscopy into the peripheral lung areas. Methods: Anaesthetised swine served as our primary model.
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Nov 6, 2023 | 01336-0&sz=64)
cell.com | Transdisciplinary Research Initiatives
Highlights•Construction of Japanese multi-omics datasets (gut microbiome, plasma metabolome, host genome)•Genome-wide association analysis of the gut microbiome with 524 Japanese individuals•ABO blood type was associated with the microbial genes related to N-galactosamine metabolism•Microbiome-metabolome association analysis highlights the association involving bile acidsSummaryInteraction between the gut microbiome and host plays a key role in human health.
