Kristle Garcia

Sep 14, 2024 | nature.com | William Connell |Kristle Garcia |Hani Goodarzi

AbstractChemical probes interrogate disease mechanisms at the molecular level by linking genetic changes to observable traits. However, comprehensive chemical screens in diverse biological models are impractical. To address this challenge, we develop ChemProbe, a model that predicts cellular sensitivity to hundreds of molecular probes and drugs by learning to combine transcriptomes and chemical structures.

Sep 14, 2024 | flipboard.com | William Connell |Kristle Garcia |Hani Goodarzi |Michael Keiser

Environment1 day agoGigantic Wave in Pacific Ocean Was The Most Extreme 'Rogue Wave' on RecordScienceAlert - Carly Cassella • 1dIn November of 2020, a freak wave came out of the blue, lifting a lonesome buoy off the coast of British Columbia 17.6 meters high (58 feet).

Aug 28, 2023 | biorxiv.org | William Connell |Kristle Garcia |Hani Goodarzi |Michael Keiser

AbstractChemical probes interrogate disease mechanisms at the molecular level by linking genetic changes to observable traits. However, comprehensive chemical screens in diverse biological models are impractical. To address this challenge, we developed ChemProbe, a model that predicts cellular sensitivity to hundreds of molecular probes and drugs by learning to combine transcriptomes and chemical structures.