Kuan-Ru Chen

Nov 6, 2024 | science.org | Yaxiong Shen |Zhenghao Li |Lucía Minarrieta |Kuan-Ru Chen

AbstractRIG-I–like receptors (RLRs) are cytosolic RNA sensors critical for antiviral immunity. RLR activation is regulated by polyubiquitination and oligomerization following RNA binding. Yet, little is known about how RLRs exploit subcellular organelles to facilitate their posttranslational modifications and activation. Endosomal adaptor TAPE regulates the endosomal TLR and cytosolic RLR pathways. The potential interplay between RIG-I signaling and endosomes has been explored.