Yaxiong Shen

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Articles

Self-adaptive photochromism

Nov 6, 2024 | science.org | Yaxiong Shen |Zhenghao Li |Lucía Minarrieta |Fanxi Sun

AbstractOrganisms with active camouflage ability exhibit changeable appearance with the switching of environments. However, manmade active camouflage systems heavily rely on integrating electronic devices, which encounters problems including a complex structure, poor usability, and high cost . In the current work, we report active camouflage as an intrinsic function of materials by proposing self-adaptive photochromism (SAP).
Endosomes serve as signaling platforms for RIG-I ubiquitination and activation

Nov 6, 2024 | science.org | Yaxiong Shen |Zhenghao Li |Lucía Minarrieta |Kuan-Ru Chen

AbstractRIG-I–like receptors (RLRs) are cytosolic RNA sensors critical for antiviral immunity. RLR activation is regulated by polyubiquitination and oligomerization following RNA binding. Yet, little is known about how RLRs exploit subcellular organelles to facilitate their posttranslational modifications and activation. Endosomal adaptor TAPE regulates the endosomal TLR and cytosolic RLR pathways. The potential interplay between RIG-I signaling and endosomes has been explored.
Mitochondrial elongation impairs breast cancer metastasis

Nov 6, 2024 | science.org | Yaxiong Shen |Zhenghao Li |Lucía Minarrieta |Matthew Annis

AbstractMitochondrial dynamics orchestrate many essential cellular functions, including metabolism, which is instrumental in promoting cancer growth and metastatic progression. However, how mitochondrial dynamics influences metastatic progression remains poorly understood. Here, we show that breast cancer cells with low metastatic potential exhibit a more fused mitochondrial network compared to highly metastatic cells.
Comparing Shor and Steane error correction using the Bacon-Shor code

Nov 6, 2024 | science.org | Yaxiong Shen |Zhenghao Li |Lucía Minarrieta |Shilin Huang

AbstractQuantum states decohere through interaction with the environment. Quantum error correction can preserve coherence through active feedback wherein quantum information is encoded into a logical state with a high degree of symmetry. Perturbations are detected by measuring the symmetries of the state and corrected by applying gates based on these measurements. To measure the symmetries without perturbing the data, ancillary quantum states are required.
Ocean weather systems on icy moons, with application to Enceladus

Nov 6, 2024 | science.org | Yaxiong Shen |Zhenghao Li |Lucía Minarrieta |Yixiao Zhang

AbstractWe explore ocean circulation on a rotating icy moon driven by temperature gradients imposed at its upper surface due to the suppression of the freezing point of water with pressure, as might be induced by ice thickness variations on Enceladus. Using high-resolution simulations, we find that eddies dominate the circulation and arise from baroclinic instability, analogous to Earth’s weather systems.
Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness

Nov 6, 2024 | science.org | Yaxiong Shen |Zhenghao Li |Lucía Minarrieta |Sidhant Chopra

AbstractA primary aim of computational psychiatry is to establish predictive models linking individual differences in brain functioning with symptoms. In particular, cognitive impairments are transdiagnostic, treatment resistant, and associated with poor outcomes. Recent work suggests that thousands of participants may be necessary for the accurate and reliable prediction of cognition, questioning the utility of most patient collection efforts.
A normative framework dissociates need and motivation in hypothalamic neurons

Nov 6, 2024 | science.org | Yaxiong Shen |Zhenghao Li |Lucía Minarrieta |Kyu Sik Kim

AbstractPhysiological needs evoke motivational drives that produce natural behaviors for survival. In previous studies, the temporally intertwined dynamics of need and motivation have made it challenging to differentiate these two components. On the basis of classic homeostatic theories, we established a normative framework to derive computational models for need-encoding and motivation-encoding neurons.
Ocean-scale patterns of environment and climate changes driving global marine phytoplankton biomass dynamics

Nov 6, 2024 | science.org | Zhenghao Li |Lucía Minarrieta |Deyong Sun |Yaxiong Shen

AbstractEffects of marine environment and climate changes on phytoplankton dynamics in global oceans have received increasing attention but remain a mystery. This study used a comprehensive approach combining correlation and information flow to explore relationships among phytoplankton biomass, marine environment, and climate forcing based on global observations over the past multi-decadal period.