Kyle M. LaPak

Dec 12, 2023 | science.org | Zbigniew Korwek |Kyle M. LaPak |Amy Baek

AbstractThe noncanonical caspase caspase-4 processes the pro form of IL-18 in response to LPS. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Inflammasomes activate caspases in response to pathogen-derived stimuli, resulting in the cleavage of gasdermin D (GSDMD) and subsequent pyroptosis and clearance of intracellular pathogens.

Dec 12, 2023 | science.org | Zbigniew Korwek |Kyle M. LaPak |Amy Baek |Soma Saeidi

Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2Kyle M. LaPak https://orcid.org/0000-0002-7571-4222, Soma Saeidi, [...] , Ilah Bok https://orcid.org/0000-0001-8958-5161, Nathan T. Wamsley, [...] , Isaac B. Plutzer https://orcid.org/0000-0002-9370-7763, Dhaval P.

Dec 12, 2023 | science.org | Zbigniew Korwek |Kyle M. LaPak |Amy Baek |Maciej Czerkies

Editor’s summaryAt the start of a viral infection, a few cells secrete type I interferons (IFNs), which stimulate transient signaling by STAT transcription factors in the infected cells and prolonged STAT signaling in bystander, uninfected cells, enabling their accumulation of antiviral proteins. Korwek et al.

Dec 12, 2023 | sciencemag.org | Zbigniew Korwek |Kyle M. LaPak |Amy Baek

Editors' ChoiceINFLAMMATIONInflammasomes activate caspases in response to pathogen-derived stimuli, resulting in the cleavage of gasdermin D (GSDMD) and subsequent pyroptosis and clearance of intracellular pathogens. Whereas canonical, caspase-1–activating inflammasomes are most associated with the production of the inflammatory cytokine interleukin-1β (IL-1β), they can also process pro–IL-18. Shi et al.