Amy Baek

Dec 3, 2024 | science.org | Xu Xu |Mahta Barekatain |Healing limitedBy |Amy Baek

AbstractActivation of liver X receptor promotes tissue regeneration over neoplastic transformation. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily The intestinal barrier is maintained by regenerative tissue repair that must be limited so that excessive regeneration associated with tumorigenesis does not occur. To investigate the mechanisms underlying this balance, Das et al.

Dec 3, 2024 | science.org | Xu Xu |Mahta Barekatain |Healing limitedBy |Amy Baek

Editor’s summaryBrown and beige adipose tissues expend energy and generate heat by oxidizing fatty acids (in a process called thermogenesis) when activated by acute cold exposure or nutrient stress. Using mice and cultured cells, Xu et al. investigated the regulation of Them1, an enzyme that diverts fatty acids from thermogenesis. During chronic cold exposure or nutrient excess, Them1 was induced by the transcription factor ChREBP, which suppressed thermogenesis.

Dec 3, 2024 | science.org | Xu Xu |Mahta Barekatain |Amy Baek |Healing limitedBy

Editor’s summaryThe rigidity and immobility caused by the progression of Parkinson’s disease are caused by loss of dopaminergic neurons in the substantia nigra. Dopamine replacement therapy offers only temporary relief with potentially severe side effects. Barekatain et al. performed structural analysis of GPR6, a G protein–coupled receptor important for the activity of dopaminergic neurons that stop movement.

Oct 29, 2024 | science.org | Vincent Rondeau |Zhigang Li |Amy Baek |Xiaxi Dong

Editor’s summaryIn contrast to the neonatal mammalian heart, in which cardiomyocyte proliferation can enable complete repair, cardiomyocytes in the adult mammalian heart must be induced to reenter the cell cycle to achieve regeneration. Increases in purine availability are required to support enhanced DNA and RNA synthesis during proliferation, leading Li et al. to investigate how cardiac regeneration is affected by Adssl1, a critical enzyme in de novo purine synthesis.

Oct 29, 2024 | science.org | Vincent Rondeau |Zhigang Li |Amy Baek

AbstractA neuropeptide-receptor pair promotes the differentiation of TH1 cells and enhances their response to viral infection. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Helper T cells, such as TH1, TH2, TH17, and Treg cells, are important in adaptive immune responses to infectious diseases, antitumor immunity, and autoimmunity.