Mohamed A. ElTanbouly

Nov 29, 2024 | biorxiv.org | Andrew MacLean |Andrew Maclean |Lachlan P. Deimel |Pengcheng Zhou |Mohamed A. ElTanbouly

AbstractIncreased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, are selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown.