Lance R. Parsons

Apr 3, 2024 | nature.com | Jun Yan |Purnima Ravisankar |Yangwode Jing |Weihao Yan |Ralf Schmidt |Sabrina C Solley | +4 more

AbstractPrime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3′ ends of CRISPR–Cas guide RNAs1. To identify cellular determinants of prime editing, we developed scalable prime editing reporters and performed genome-scale CRISPR-interference screens.

Mar 20, 2023 | nature.com | Beryl M Jones |Olga Dudchenko |Ian M. Traniello |Karen M. Kapheim |Lance R. Parsons |Matthew McBride | +8 more

AbstractSweat bees have repeatedly gained and lost eusociality, a transition from individual to group reproduction. Here we generate chromosome-length genome assemblies for 17 species and identify genomic signatures of evolutionary trade-offs associated with transitions between social and solitary living. Both young genes and regulatory regions show enrichment for these molecular patterns.