Larysa V. Yuzefovych

Sep 12, 2023 | mdpi.com | Larysa V. Yuzefovych |Madhuri S Mulekar |Kate Ledbetter |Viktor M. Pastukh

1. IntroductionObesity is associated with insulin resistance (IR), and this represents a major risk factor for metabolic syndrome (MetS), type 2 diabetes (T2D), and cardiovascular disorders such as coronary artery disease and heart failure [1,2]. It has been demonstrated that mitochondrial dysfunction contributes to obesity-related IR [3,4,5]. Previously, we and others showed that bariatric surgery rapidly improves mitochondrial respiration in morbidly obese patients [6,7].