Laura A. Hruby

Mar 8, 2024 | biorxiv.org | Laura A. Hruby |Katerina Scharov |Alberto Delaidelli |Daniel Picard

AbstractMedulloblastoma (MB) is the most common malignant brain tumor in childhood and is stratified into four molecular groups ‒ WNT, SHH, Group 3 and Group 4. Group 3 MB patients exhibit the poorest prognosis, with a 5-year overall survival of <60%, followed by Group 4 MB patients. Apart from MYC amplification in a subset of Group 3 MBs, the molecular pathomechanisms driving aggressiveness of these tumors remain incompletely characterized.