Alberto Delaidelli

Sep 30, 2024 | biorxiv.org | Lin Evlin |Nanna M. Jensen |Sara Ferreira |Alberto Delaidelli

AbstractA pathological role of alpha-Synuclein (aSyn) aggregation in the central nervous system (CNS) is a recognized feature in Parkinson disease (PD) and related neurodegenerative conditions termed synucleinopathies.

Mar 8, 2024 | biorxiv.org | Laura A. Hruby |Katerina Scharov |Alberto Delaidelli |Daniel Picard

AbstractMedulloblastoma (MB) is the most common malignant brain tumor in childhood and is stratified into four molecular groups ‒ WNT, SHH, Group 3 and Group 4. Group 3 MB patients exhibit the poorest prognosis, with a 5-year overall survival of <60%, followed by Group 4 MB patients. Apart from MYC amplification in a subset of Group 3 MBs, the molecular pathomechanisms driving aggressiveness of these tumors remain incompletely characterized.

Feb 27, 2024 | mdpi.com | Alberto Delaidelli |Alessandro Moiraghi

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Jan 18, 2024 | cell.com | Alberto Delaidelli |Poul H Sorensen

Hofman et al. reveal a novel survival mechanism in high-risk childhood medulloblastoma through the translation of non-canonical open reading frames (ORFs). The study uncovers the critical role of these often-overlooked ORFs, particularly the ASNSD1-uORF, in medulloblastoma cell survival, offering new avenues for targeted therapies in pediatric cancer.

May 15, 2023 | mdpi.com | Betty Yao |Alberto Delaidelli |Hannes Vogel |Poul H Sorensen

This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReviewbyBetty Yao 1, Alberto Delaidelli 1,2, Hannes Vogel 3 and Poul H.