Laurel Stine

1 week ago | hanfordsentinel.com | Aneri Pattani |Laurel Stine

Since President Donald Trump released his 2026 budget blueprint in early May, calling for $163 billion in federal spending cuts, much of the attention has focused on his slashing of foreign aid and boosting of border security. But the proposal also holds important clues — amid some mixed messages — about the administration’s approach to two pressing public health issues: mental health and addiction.

2 months ago | biorxiv.org | Sara Cahill |Matthew Finnegan |Laurel Stine |Shriram Ramani

AbstractIntracellular sensing of lipopolysaccharide is an essential component of pathogen detection that governs the innate immune response. However, how this process is controlled to maintain homeostasis and resolve inflammation is unclear. Here we show that MARCO is a macrophage decoy LPS sensor crucial for restraining caspase 11 activity and the non-canonical inflammasome. Remarkably, MARCO expression is controlled by the metabolite itaconate and the transcription factor NRF2.