Sara Cahill

Mar 13, 2025 | biorxiv.org | Sara Cahill |Matthew Finnegan |Laurel Stine |Shriram Ramani

AbstractIntracellular sensing of lipopolysaccharide is an essential component of pathogen detection that governs the innate immune response. However, how this process is controlled to maintain homeostasis and resolve inflammation is unclear. Here we show that MARCO is a macrophage decoy LPS sensor crucial for restraining caspase 11 activity and the non-canonical inflammasome. Remarkably, MARCO expression is controlled by the metabolite itaconate and the transcription factor NRF2.