Lauren Enten

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234. Low-Intensity Focused Ultrasound (FUS) Amygdala Neuromodulation: An fMRI Target Engagement Study and Open-Label Treatment Trial in Mixed Mood, Anxiety, and Trauma-Related Disorders

Apr 29, 2024 | biologicalpsychiatryjournal.com | Lauren Enten |Annamarie DeMarco |Rachel Kline |Bryan Barksdale

Affective disorders (ADs), i.e. mood, anxiety, and trauma-related disorders, show common amygdala (AMYG) hyperactivity to emotional cues. Low-intensity focused ultrasound (FUS) can modulate brain function in subcortical areas. Here, using concurrent FUS/functional magnetic resonance imaging (fMRI), we tested FUS modulation of the left AMYG in AD patients (N=23) and healthy controls (HCs)(N=23).
42. Posttraumatic Stress Disorder (PTSD) is Associated With Abnormal Amygdala and Striatal Signaling of Temporal Prediction Errors During a Passive Reward Learning Task

Feb 22, 2024 | biologicalpsychiatryjournal.com | Gregory A. Fonzo |Lauren Enten |Annamarie DeMarco |Rachel Kline

Posttraumatic stress disorder (PTSD) is characterized by diminished positive affect (DPA), but the neurobiology of these symptoms is not well understood. Prior studies report abnormal prediction error signaling in PTSD, i.e. discrepancies between expected vs. actual rewards. None have investigated violation of temporal cue-outcome relationships, which induce temporal prediction errors (TPEs) to signal differences between expected vs. actual timing of rewards.

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