Gregory A. Fonzo

Apr 29, 2024 | biologicalpsychiatryjournal.com | Gregory A. Fonzo

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Apr 29, 2024 | biologicalpsychiatryjournal.com | Hao Yue Zhu |Xiaoyu Tong |Gregory A. Fonzo |Desmond J. Oathes

Major depressive disorder (MDD) has persisted over an extended period. However, comprehension of MDD remains elusive, particularly concerning the disorder-relevant brain alterations and their association with symptoms. Contrastive learning techniques offer a new avenue for distilling patient-specific variability from background heterogeneity, facilitating the identification of association between functional connectivity and symptom profiles in MDD patients.

Feb 22, 2024 | biologicalpsychiatryjournal.com | Gregory A. Fonzo |Lauren Enten |Annamarie DeMarco |Rachel Kline

Posttraumatic stress disorder (PTSD) is characterized by diminished positive affect (DPA), but the neurobiology of these symptoms is not well understood. Prior studies report abnormal prediction error signaling in PTSD, i.e. discrepancies between expected vs. actual rewards. None have investigated violation of temporal cue-outcome relationships, which induce temporal prediction errors (TPEs) to signal differences between expected vs. actual timing of rewards.