Laurent Hocqueloux

Aug 19, 2024 | sti.bmj.com | Julien Flaig |Laurent Hocqueloux |Romain Palich |Lise Cuzin

DiscussionThe rising epidemiology of NG and CT infections in MSM is challenging and measuring the impact of interventions remains difficult. In this modelling study, we demonstrate that increasing either the testing frequency or the number of frequently tested patients (such as PrEP-users) would have a limited impact on NG and CT incidence in the total French MSM population.

May 24, 2024 | sti.bmj.com | Julien Flaig |Laurent Hocqueloux |Romain Palich |Lise Cuzin

AbstractObjectives The impact of the systematic screening of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) in men having sex with men (MSM) on these pathogens’ epidemiology remains unclear. We conducted a modelling study to analyse this impact in French MSM. Methods We modelled NG and CT transmission using a site-specific deterministic compartmental model. We calibrated NG and CT prevalence at baseline using results from MSM enrolled in the Dat’AIDS cohort.

Oct 10, 2023 | nature.com | Luis M. Molinos-Albert |Pierre Rosenbaum |Thierry Hieu |Dominique Clermont |Jordan Dimitrov |Sophie Hue | +1 more

AbstractHIV-1 infection causes severe alterations of gut mucosa, microbiota and immune system, which can be curbed by early antiretroviral therapy. Here, we investigate how treatment timing affects intestinal memory B-cell and plasmablast repertoires of HIV-1-infected humans. We show that only class-switched memory B cells markedly differ between subjects treated during the acute and chronic phases of infection.

Feb 14, 2023 | nature.com | Timothée Bruel |Françoise Porrot |Piet Maes |Nathalie Morel |Jérémy Dufloo |Rafael Sanjuán | +2 more

AbstractConvergent evolution of SARS-CoV-2 Omicron BA.2, BA.4, and BA.5 lineages has led to the emergence of several new subvariants, including BA.2.75.2, BA.4.6. and BQ.1.1. The subvariant BQ.1.1 became predominant in many countries in December 2022. The subvariants carry an additional and often redundant set of mutations in the spike, likely responsible for increased transmissibility and immune evasion. Here, we established a viral amplification procedure to easily isolate Omicron strains.