Lei Qi

Nov 7, 2024 | cell.com | Chun Ching Liu |Mengcheng Shen |Yanxia Liu |Amit Manhas |Shane Zhao |Mao Zhang | +14 more

Keywordsdoxorubicincardio-oncologyCRISPR screeniPSCcarbonic anhydrasecardiomyoctyeglycolysisGet full text accessLog in, subscribe or purchase for full access. References1. Miller, K.D. ∙ Nogueira, L. ∙ Devasia, T. ... Cancer treatment and survivorship statistics, 2022CA Cancer J. Clin. 2022; 72:409-4362. Burridge, P.W. ∙ Li, Y.F. ∙ Matsa, E. ... Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicityNat. Med.

Jun 12, 2024 | nature.com | Yitong Ma |Lei Qi

The inaugural CRISPR-based drug Casgevy has been approved by several medical agencies, with other CRISPR-based therapies currently in clinical trials. Although there are technological hurdles to overcome, chemical biology has a vital role in developing recent breakthroughs in base editing, prime editing and epigenetic editing into future treatments.

Apr 1, 2024 | nature.com | Lei Qi

The quest for safer therapeutic alternatives to genome editing heralds epigenome editing as a promising approach. In a recent study published in Nature, Cappelluti et al. demonstrated robust, long-term Pcsk9 silencing in vivo with a single administration of epigenetic effectors delivered by lipid nanoparticles, marking a significant stride towards the clinic for epigenetic editing therapies.

Nov 8, 2023 | onlinelibrary.wiley.com | Lei Qi |Wei Zhao |Xiaofeng Sun |Xin Li

REFERENCES 1, , , , , . Grid-synchronization stability of converter-based resources—an overview. IEEE Open J Ind Appl. 2020; 1: 115-134. doi:10.1109/OJIA.2020.3020392 2, , , , . Transformed periodic orbit mechanism of low frequency oscillations in power systems. Int J Circ Theory Appl. 2016; 44(1): 226-239. doi:10.1002/cta.2073 3, , . Seamless transfer control for dual-mode grid-connected inverter with automatic PCC voltage regulation. Int J Circ Theor Appl. 2022; 50(11): 4070-4085.

Feb 2, 2023 | cell.com | Howard Chang |Lei Qi |Chan Zuckerberg Biohub |Sarafan ChEm-H

Sabin L. Delás M. Hannon G. Dogma derailed: the many influences of RNA on the genome. Mol Cell. 2013; 49: 783-794https://doi.org/10.1016/j.molcel.2013.02.010Millman A. Bernheim A. Stokar-Avihail A. Fedorenko T. Voichek M. Leavitt A. Oppenheimer-Shaanan Y. Sorek R. Bacterial Retrons Function In Anti-Phage Defense. Cell. 2020; 183: 1551-1561.e12https://doi.org/10.1016/j.cell.2020.09.065Hsu P. Lander E. Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell.