Leif Schröder

Oct 22, 2024 | nature.com | Henri de Maissin |Andrey N. Pravdivtsev |Arne Brahms |Leif Schröder |Eduard Y Chekmenev |Rainer Herges

AbstractHyperpolarized 13C MRI visualizes real-time metabolic processes in vivo. In this study, we achieved high 13C polarization in situ in the bore of an MRI system for precursor molecules of most widely employed hyperpolarized agents: [1-13C]acetate and [1-13C]pyruvate ethyl esters in their perdeuterated forms, enhancing hyperpolarization lifetimes, hyperpolarized to P13C ≈ 28% at 80 mM concentration and P13C ≈ 19% at 10 mM concentration, respectively.