Arne Brahms

Dec 2, 2024 | nature.com | Xin Gui |Oleg Salnikov |Arne Brahms |Eduard Y Chekmenev |Rainer Herges |Simon B Duckett | +2 more

AbstractThe signal amplification by reversible exchange process (SABRE) enhances NMR signals by unlocking hidden polarization in parahydrogen through interactions with to-be-hyperpolarized substrate molecules when both are transiently bound to an Ir-based organometallic catalyst. Recent efforts focus on optimizing polarization transfer from parahydrogen-derived hydride ligands to the substrate in SABRE.

Oct 22, 2024 | nature.com | Henri de Maissin |Andrey N. Pravdivtsev |Arne Brahms |Leif Schröder |Eduard Y Chekmenev |Rainer Herges

AbstractHyperpolarized 13C MRI visualizes real-time metabolic processes in vivo. In this study, we achieved high 13C polarization in situ in the bore of an MRI system for precursor molecules of most widely employed hyperpolarized agents: [1-13C]acetate and [1-13C]pyruvate ethyl esters in their perdeuterated forms, enhancing hyperpolarization lifetimes, hyperpolarized to P13C ≈ 28% at 80 mM concentration and P13C ≈ 19% at 10 mM concentration, respectively.

Aug 23, 2023 | science.org | Sarah Hoy |Josh Peters |Runzi Sun |Arne Brahms

INTRODUCTIONA well-balanced energy metabolism is critical for all living species. For example, glucose metabolism is altered in diabetes (1), Pompe disease (2), and cancer (3, 4). Detecting metabolic alterations fast, noninvasively, in vivo, and in real time is a promising approach to improve the understanding, diagnosis, and treatment of diseases. Many efforts have been invested in such imaging techniques.

Aug 8, 2023 | nature.com | Frowin Ellermann |Arne Brahms |Rainer Herges |Jan-Bernd Hövener |Aidan Sirbu

AbstractNuclear spin hyperpolarization is a quantum effect that enhances the nuclear magnetic resonance signal by several orders of magnitude and has enabled real-time metabolic imaging in humans. However, the translation of hyperpolarization technology into routine use in laboratories and medical centers is hampered by the lack of portable, cost-effective polarizers that are not commercially available.

Jun 30, 2023 | pubs.acs.org | Arne Brahms |Andrey N. Pravdivtsev |Frank D. Sönnichsen |Lynn Thorns

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