Lejin Yang

Sep 26, 2024 | nature.com | Xuan Zhang |Guibing Liu |Xiu Li |Peng Xiao |Jin-Peng Sun |Lejin Yang

AbstractHistamine is a biogenic amine that is critical in various physiological and pathophysiological processes, including but not limited to allergic reactions, wakefulness, gastric acid secretion and neurotransmission. Here, we determine 9 cryo-electron microscopy (cryo-EM) structures of the 4 histamine receptors in complex with four different G protein subtypes, with endogenous or synthetic agonists bound.