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Oct 29, 2024 | 
onlinelibrary.wiley.com | Charlotte Micheloud |Leonhard Held
1 Introduction Replicability of scientific findings is the gold standard for assessing their credibility. Recent years have witnessed an increased interest in large-scale replication projects, aiming to reproduce the results found in an original study in one or several replication studies. Various empirical domains of science are involved in these replication efforts: psychology (Open Science Collaboration 2015), social sciences (Camerer et al. 2016), economics (Camerer et al.
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Oct 23, 2024 | 
onlinelibrary.wiley.com | Leonhard Held
REPLY Response to Nadarajah First published: 23 October 2024 No abstract is available for this article. References 1S. Nadarajah, “Letter to the Editors,” Statistics in Medicine 43, no. 26 (2024): 5043–5045. 2L. Held, “Beyond the Two-Trials Rule,” Statistics in Medicine 43, no. 26 (2024): 5023–5042. 3W. H. Press, S. A. Teukolsky, W. T. Vetterling, and B. P. Flannery, Numerical Recipes—The Art of Scientific Computing, 3rd ed. (Cambridge, UK: Cambridge University Press, 2007). 4L.
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May 13, 2024 | 
elifesciences.org | Samuel Pawel |Rachel Heyard |Charlotte Micheloud |Leonhard Held
eLife assessment This work provides a valuable contribution and assessment of what it means to replicate a null study finding, and what are the appropriate methods for doing so (apart from a rote p-value assessment).
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Apr 10, 2024 | 
dialnet.unirioja.es | Samuel Pawel |Frederik Aust |Leonhard Held |Eric-Jan Wagenmakers
Samuel Pawel[1];Frederik Aust[2];Leonhard Held[1];Eric-Jan Wagenmakers[2][1]University of Zurich[2]University of AmsterdamLocalización: Test: An Official Journal of the Spanish Society of Statistics and Operations Research, ISSN-e 1863-8260, ISSN 1133-0686, Vol. 33, Nº. 1, 2024, págs. 127-154Idioma: inglésTexto completo no disponible (Saber más ...)ResumenThe ongoing replication crisis in science has increased interest in the methodology of replication studies.
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Apr 4, 2024 | 
onlinelibrary.wiley.com | Leonhard Held
1 INTRODUCTION The two trials rule is a standard requirement by the FDA to demonstrate efficacy of drugs. It demands “at least two pivotal studies, each convincing on its own”1 before drug approval is granted and “reflects the need for substantiation of experimental results, which has often been referred to as the need for replication of the finding”. 2 The rule is usually implemented by requiring two independent studies to be significant at the standard (one-sided) α = 0 .
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Feb 17, 2024 | 
onlinelibrary.wiley.com | Anne-Laure Boulesteix |Mark T. Baillie |Dominic Edelmann |Leonhard Held
Biomedical researchers are frequently faced with an array of methods they might potentially use for the analysis and/or design of studies. It can be difficult to understand the absolute and relative merits of candidate methods beyond one's own particular interests and expertise. Choosing a method can be difficult even in simple settings but an increase in the volume of data collected, computational power, and methods proposed in the literature makes the choice all the more difficult.
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Feb 1, 2024 | 
bmjmedicine.bmj.com | Rachel Heyard |Leonhard Held |Sebastian Schneeweiss |Shirley Wang
Design differences and variation in results between randomised trials and non-randomised emulations: meta-analysis of RCT-DUPLICATE data Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
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Aug 26, 2023 | 
onlinelibrary.wiley.com | Annette Kopp-Schneider |Manuel Wiesenfarth |Leonhard Held |Silvia Calderazzo
1 INTRODUCTION When trials can only be performed with small sample sizes as, for example, in the situation of precision medicine where patients cohorts are defined by a specific combination of biomarker and targeted therapy, borrowing information from historical data is currently discussed as an approach to improve the efficiency of the trial.
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Jun 20, 2023 | 
onlinelibrary.wiley.com | Charlotte Micheloud |Fadoua Balabdaoui |Leonhard Held
1 INTRODUCTION Replication plays a key role to build confidence in the scientific merit of published results. The so-called replication crisis has led to increased interest in replication studies over the last decade (National Academies of Sciences, Engineering, and Medicine, 2019; Royal Netherlands Academy of Arts and Science, 2018) with large-scale replication projects being conducted in various fields (Camerer et al., 2016, 2018; Errington et al., 2021; Open Science Collaboration, 2015).
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May 30, 2023 | 
pubmed.ncbi.nlm.nih.gov | Simon Schwab |Leonhard Held
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