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2 months ago | 00372-3/abstract?rss=yes&sz=64)
thelancet.com | Leslie Dan Faculty |Carma Henry |Fort Lauderdale
FREE with registration!Log in or register to access the full article. References1. International Diabetes FederationIDF Diabetes Atlas, 10th edition2. Sinclair, A ∙ Saeedi, P ∙ Kaundal, A ∙ et al. Diabetes and global ageing among 65–99-year-old adults: findings from the International Diabetes Federation Diabetes Atlas, 9th editionDiabetes Res Clin Pract. 2020; 162, 1080783. CDCPrevalence of both diagnosed and undiagnosed diabetes4. Munshi, MN ∙ Meneilly, GS ∙ Rodríguez-Mañas, L ∙ et al.
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Jan 9, 2025 | 
winnipegfreepress.com | Catherine Donnelly |Jennifer Lake |Leslie Dan Faculty |Jordan Miller
This article was originally published on The Conversation, an independent and nonprofit source of news, analysis and commentary from academic experts. Disclosure information is available on the original site.
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Sep 6, 2024 | 
bmccancer.biomedcentral.com | Francis Xavier |Leslie Dan Faculty |Toronto Metropolitan
A total of 38,788 individuals were diagnosed with lung cancer between April 1, 2012 and March 31, 2017 including 2,696 immigrants (7%) and 36,092 long-term residents (93%) (Fig. 1). Baseline characterteristics of the study cohort have been previously published [10]. Approximately 49.3% of the cohort was female and 26.5% of the total cohort was diagnosed with early-stage lung cancer.
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Sep 5, 2024 | 
agsjournals.onlinelibrary.wiley.com | Todd Lee |Émilie Bortolussi-Courval |Lisa McCarthy |Leslie Dan Faculty
Corresponding Author Todd C. Lee MD, MPH, FIDSA Clinical Practice Assessment Unit, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada Division of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada Correspondence Todd C.
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Aug 23, 2024 | 00222-4&sz=64)
cell.com | Carolyn Cummins |Leslie Dan Faculty |Ido Goldstein
Abstract Glucocorticoids (GCs) are potent anti-inflammatory drugs. A new study by Auger et al. found that GCs increase itaconate, an anti-inflammatory tricarboxylic acid (TCA) cycle intermediate, by promoting movement of cytosolic pyruvate dehydrogenase (PDH) to mitochondria. Itaconate was sufficient for mediating the anti-inflammatory effects of GCs in mice, overriding the notion that nuclear glucocorticoid receptor (GR) is necessary for inflammation inhibition.
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Aug 21, 2024 | 
academic.oup.com | Luis David |Leslie Dan Faculty
The development and maintenance of chronic pain involves the reorganization of spinal nociceptive circuits. The mechanistic target of rapamycin complex 2 (mTORC2), a central signaling hub that modulates both actin-dependent structural changes and mTORC1-dependent mRNA translation, plays key roles in hippocampal synaptic plasticity and memory formation. However, its function in spinal plasticity and chronic pain is poorly understood.
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Jul 18, 2024 | 
onlinelibrary.wiley.com | Shufen Xu |Leslie Dan Faculty |Yue Xu |Nicholas C. Solek
Bowen Li Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 3M2 Canada Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, M5G 2C1 CanadaSearch for more papers by this author
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Jun 19, 2024 | 00416-8&sz=64)
cell.com | Leslie Dan Faculty
Get full text accessLog in, subscribe or purchase for full access. References1. Bretscher, M.S.Asymmetrical lipid bilayer structure for biological membranesNat. New Biol. 1972; 236:11-122. Krompers, M. ∙ Heerklotz, H. A Guide to Your Desired Lipid-Asymmetric VesiclesMembranes. 2023; 13:2673. Drabik, D. ∙ Hinc, P. ∙ Dimova, R. ... Effect of leaflet asymmetry on the stretching elasticity of lipid bilayers with phosphatidic acidBiophys. J. 2024; 123:2422-24304. Eicher, B. ∙ Marquardt, D. ...
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Jun 6, 2024 | 00128-9/fulltext&sz=64)
thelancet.com | Leslie Dan Faculty
The COVID-19 pandemic has been marked by the emergence of SARS-CoV-2 variants. 1Harvey WT Carabelli AM Jackson B et al. SARS-CoV-2 variants, spike mutations and immune escape. Collectively, these variants have been associated with increased transmissibility, risk of reinfection, disease severity, and evasion of immunity from natural infection and vaccinations. 1Harvey WT Carabelli AM Jackson B et al. SARS-CoV-2 variants, spike mutations and immune escape.
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May 30, 2024 | 
podcasts.apple.com | Leslie Dan Faculty
The internet is full of examples of failed innovations... The Segway, The PalmPilot, MySpace... tech that started revolutions, but failed to scale. This phenomenon is not specific to Silicon Valley. In fact, it is very present in healthcare. On this episode of the I'm Pharmacy Podcast, we chat diffusion and implementation. What can innovators learn from failed innovatrions to better navigate the healthcare market?
