Lewis T. Ibbotson

Apr 16, 2024 | pubs.rsc.org | Lennart Brewitz |Lewis T. Ibbotson |Shyam Basak |Eidarus Saleh

Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation Enzyme inhibitors working by O-acylation of nucleophilic serine residues are of immense medicinal importance, as exemplified by the β-lactam antibiotics. By contrast, inhibition of nucleophilic cysteine enzymes by S-acylation has not been widely exploited for medicinal applications.