Lennart Brewitz

Jun 28, 2024 | vt.se | Lennart Brewitz

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Jun 13, 2024 | pubs.acs.org | Lennart Brewitz |Christopher J Schofield |R. E. Scott |Charlotte M. N

FiguresReferencesSupport InfoFigure 1 This article references 56 other publications. 1Owen, D. R.; Allerton, C. M. N.; Anderson, A. S.; Aschenbrenner, L.; Avery, M.; Berritt, S.; Boras, B.; Cardin, R. D.; Carlo, A.; Coffman, K. J. An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.

Apr 23, 2024 | vt.se | Lennart Brewitz

Lokalt Visa alla orter Västervik Gamleby Överum Loftahammar Ankarsrum Gunnebo Blankaholm Totebo Hjorted Vimmerby Kalmar län Sport Visa all sport Livesport Senaste nytt Fotboll Ishockey Speedway Hästsport Innebandy Resultat Familj Familjenyheter Se dödsannonser (Till minne) Se familjeannonser Se köp och sälj Skicka in minnesord Skicka in familjeannonser Skicka in Dagens ros Skicka in föreningsbrev Åsikter Alla åsikter Ledare Krönikor Skriv en insändare eller debattartikel Övrigt Korsord Quiz...

Apr 16, 2024 | pubs.rsc.org | Lennart Brewitz |Lewis T. Ibbotson |Shyam Basak |Eidarus Saleh

Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation Enzyme inhibitors working by O-acylation of nucleophilic serine residues are of immense medicinal importance, as exemplified by the β-lactam antibiotics. By contrast, inhibition of nucleophilic cysteine enzymes by S-acylation has not been widely exploited for medicinal applications.

Oct 2, 2023 | pubs.rsc.org | Mariska de Munnik |Jasper Lithgow |Lennart Brewitz |Kirsten Christensen

αβ,α′β′-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes† Epoxides are an established class of electrophilic alkylating agents that react with nucleophilic protein residues. We report αβ,α′β′-diepoxyketones (DEKs) as a new type of mechanism-based inhibitors of nucleophilic cysteine enzymes.