Li-Hua Ma

1 month ago | digitalcommons.library.tmc.edu | Jialin Sun |Sivan Osenberg |Austin Irwin |Li-Hua Ma

KeywordsHumans, Astrocytes, Methyl-CpG-Binding Protein 2, Rett Syndrome, Neurons, Brain, MutationAbstractMutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most commonly Rett syndrome (RTT). We ask whether MECP2 mutations interfere with human astrocyte developmental maturation, thereby affecting their ability to support neurons.