Liam M. Koehn

Nov 17, 2023 | dx.doi.org | Liam M. Koehn |Joel Steele |Ralf B. Schittenhelm |Bradley Turner

Amyotrophic lateral sclerosis (ALS) is characterized by death and dysfunction of motor neurons that result in a rapidly progressing loss of motor function. While there are some data on alterations at the blood–brain barrier (BBB) in ALS and their potential impact on CNS trafficking of drugs, little is reported on the impact of this disease on the expression of drug-handling proteins in the small intestine and liver.