Liang-Fu Chen

Mar 29, 2023 | cell.com | Liang-Fu Chen |Hannah Long |Minhee Park |Tomek Swigut

Enhancer clusters overlapping disease-associated mutations in Pierre Robin sequence (PRS) patients regulate SOX9 expression at genomic distances over 1.25 Mb. Chen and Long et al. trace the 3D topology of the SOX9 locus during PRS-enhancer activation and identify structural elements that promote domain-wide interactions and facilitate ultra-long-range gene regulation.