Minhee Park

Apr 24, 2024 | nature.com | Minhee Park

AbstractRecent studies have demonstrated that the three-dimensional conformation of the chromatin plays a crucial role in gene regulation, with aberrations potentially leading to various diseases. Advanced methodologies have revealed a link between the chromatin conformation and biological function. This review divides these methodologies into sequencing-based and imaging-based methodologies, tracing their development over time.

Mar 29, 2023 | cell.com | Liang-Fu Chen |Hannah Long |Minhee Park |Tomek Swigut

Enhancer clusters overlapping disease-associated mutations in Pierre Robin sequence (PRS) patients regulate SOX9 expression at genomic distances over 1.25 Mb. Chen and Long et al. trace the 3D topology of the SOX9 locus during PRS-enhancer activation and identify structural elements that promote domain-wide interactions and facilitate ultra-long-range gene regulation.