Lianrong Wang

Nov 5, 2024 | nature.com | Susu Jiang |Chao Chen |Zixin Deng |Lianrong Wang |Lixu Jiang

AbstractDNA degradation (Dnd) is a widespread bacterial antiphage defence system that relies on DNA phosphorothioate (PT) modification for self/non-self discrimination and subsequent degradation of unmodified DNA. Phages employ counterstrategies to evade host immunity, but anti-Dnd immunity has not been characterized. Here we report an immune evasion protein encoded by the Salmonella phage JSS1 that contributes to subverting Dnd and other defence systems.

May 29, 2024 | nature.com | Lianrong Wang

AbstractSterol regulatory element binding transcription factors (SREBPs) play a crucial role in lipid homeostasis. They are processed and transported to the nucleus via COPII, where they induce the expression of lipogenic genes. COPII maintains the homeostasis of organelles and plays an essential role in the protein secretion pathways in eukaryotes.

Mar 12, 2024 | nature.com | Jing Li |Rui Cheng |Zhiming Wang |Jun Xiao |Shiyu Xia |Lianrong Wang | +1 more

AbstractProkaryotes have evolved intricate innate immune systems against phage infection1-7. Gabija is a highly abundant prokaryotic defense system consisting of two components, GajA and GajB8. We previously demonstrated that GajA functions as a DNA endonuclease that is inactive in the presence of ATP9.