Susu Jiang

Nov 5, 2024 | nature.com | Susu Jiang |Chao Chen |Zixin Deng |Lianrong Wang |Lixu Jiang

AbstractDNA degradation (Dnd) is a widespread bacterial antiphage defence system that relies on DNA phosphorothioate (PT) modification for self/non-self discrimination and subsequent degradation of unmodified DNA. Phages employ counterstrategies to evade host immunity, but anti-Dnd immunity has not been characterized. Here we report an immune evasion protein encoded by the Salmonella phage JSS1 that contributes to subverting Dnd and other defence systems.