Liliane Eleid

Jul 2, 2024 | science.org | Yusman Manchanda |Zhongbo Li |Leslie K. Ferrarelli |Liliane Eleid

Editor’s summaryMini-G proteins are engineered forms of Gα subunits that stably interact with activated G protein–coupled receptors (GPCRs) and are often used to investigate GPCR signaling from specific subcellular compartments. Manchanda et al. found that mini-G proteins interfered with GPCR internalization and compartmentalized signaling.