Yusman Manchanda

Jul 2, 2024 | science.org | Yusman Manchanda |Zhongbo Li |Leslie K. Ferrarelli |Peng Su

Editor’s summaryThe transcriptional cofactor YAP is usually associated with tumor progression. However, Li et al. found that YAP has a tumor-suppressive role in clear cell renal cell carcinoma (ccRCC) by outcompeting another transcription factor for a binding partner. The proliferation of ccRCC cells was driven by the NF-κB subunit p65 in complex with the cofactor TEAD. YAP competed for TEAD binding, displacing p65 and preventing its transcriptional activity.

Jul 2, 2024 | science.org | Yusman Manchanda |Zhongbo Li |Leslie K. Ferrarelli |Liliane Eleid

Editor’s summaryMini-G proteins are engineered forms of Gα subunits that stably interact with activated G protein–coupled receptors (GPCRs) and are often used to investigate GPCR signaling from specific subcellular compartments. Manchanda et al. found that mini-G proteins interfered with GPCR internalization and compartmentalized signaling.

Jul 2, 2024 | science.org | Yusman Manchanda |Zhongbo Li |Leslie K. Ferrarelli

Editors' ChoiceADDICTIONLeslie K. Ferrarelli [email protected] Info & AffiliationsAbstractOpioids trigger myelin insulation of reward circuit axons in a feedforward loop of addiction. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Addiction results from persistent changes in the function of the dopamine reward circuit in the brain. Yalçın et al.