Lin Guo

Nov 21, 2024 | biorxiv.org | Jie Liu |Jing Gao |Lin Guo |Guoming Ma

AbstractSecreted proteins mediate intercellular communication throughout the lives of multicellular organisms. However, due to the lack of new technology for secreted protein capturing, the progress of "secretomics" lags behind. Here, we report a two-step secretome enrichment method (tsSEM) combining unnatural amino acid labeling and click chemistry-based biorthogonal reaction, which enables in vitro secretome profiling in the presence of serum.

Oct 29, 2024 | healtheconomicsreview.biomedcentral.com | Yulin Chai |Ying Liu |LinLin Zhang |Dan Chen |Wenqiang Yin |Lin Guo

When examining the impact of PHR on the mismatch of medical resources, quantile regression is effective in revealing the heterogeneous effects of the policy across different levels of mismatch. The study performs quantile regressions at the 5th, 25th, 50th, 75th, and 95th percentiles. The specific results are shown in Panel A of Table 6: PHR has a greater impact at the lower percentiles (5% and 25%), while its effect is insignificant at the median (50%).

Jul 1, 2024 | mdpi.com | Yuanyuan Chen |Lin Guo |Jia Xu |Qiang Yang

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Nov 22, 2023 | arthritis-research.biomedcentral.com | Daniel Solomon |Hongshu Guan |Fredrik Johansson |Leah M. Santacroce |Lin Guo |Heather J. Litman | +1 more

We used the CorEvitas RA registry to identify a cohort of patients potentially eligible. From this group, patients were required to have at least 6 years of experience in the registry, between 2011 and 2021, but patients could have entered the CorEvitas before 2011. The first visit in the CorEvitas RA registry was considered baseline with follow-up through the last visit in the registry.

Sep 27, 2023 | nature.com | Hewei Zhao |Lin Guo

Oxide glasses can be intrinsically toughened by forming crystal-like, medium-range order clusters, which transform inversely to the amorphous state under stress, exciting multiple shear bands for plastic deformation. With their history traced back to 3500 bc, glasses have been considered as one of the most important materials for humankind with huge contributions to human civilization.