Linda Charlotte Zirden

Feb 2, 2024 | biorxiv.org | Joel Brenner |Yasser Almeida-Hernandez |Farnusch Kaschani |Linda Charlotte Zirden

AbstractHsp70/Hsp90-chaperones and their regulatory co-chaperones are critical for maintaining protein homeostasis. GRP94, the sole Hsp90-chaperone in the secretory pathway of mammalian cells, is essential for the maturation of important secretory and transmembrane proteins. Without the requirement of co-chaperones, the Hsp70-protein BiP controls regulatory conformational changes of GRP94 – the structural basis of which has remained elusive.