Ling-Ling Chen

Jan 19, 2025 | nature.com | Ling-Ling Chen

Although small nucleolar RNAs (snoRNAs) are well-known for guiding 2′-O-methylation and pseudouridine modification on ribosomal RNAs and small nuclear RNAs, their additional functions have remained largely undefined.

Nov 15, 2024 | digitalcommons.library.tmc.edu | Ling-Ling Chen |Albrecht Bindereif |Irene Bozzoni |Howard Chang

KeywordsRNA, Circular, Eukaryota, RNA, Eukaryotic Cells, Alternative splicing, back-splicing, back-splice junction, circRNA, ciRNA, nomenclatureAbstractAlternative splicing of eukaryotic transcripts often leads to production of multiple mature RNAs from a single gene locus.

Oct 27, 2024 | nature.com | Ling-Ling Chen

Optimized methods for the synthesis of circular RNA in vitro and in cells, and a complementary Cas9 de-immunization method, enhance RNA persistence and reduce immunogenicity for applications in genome engineering and cell engineering.