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1 month ago | 
preprints.org | Wyatt Madden |Meng Qi |Yang Liu |Howard Chang
You are already at the latest version Ambient fine particulate matter of size less than 2.5 µm in aerodynamic diameter (PM2.5) is a key component of ambient air pollution that has been linked to numerous adverse health outcomes. Reliable estimates of PM2.5 are important for supporting epidemiologic and health impact assessment studies. Precise measurements of PM2.5 are available through networks of monitors, however these are spatially sparse and temporally incomplete.
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1 month ago | 
nature.com | Jung-Ki Yoon |Yili Zhu |John Lu |Georgios Mikos |Camille Brenac |Nicholas J. Guardino | +6 more
AbstractFibrosis, the replacement of healthy tissue with collagen-rich matrix, can occur following injury in almost every organ1,2. Mouse lungs follow a stereotyped sequence of fibrogenesis-to-resolution after bleomycin injury3, and we reasoned that profiling post-injury histological stages could uncover pro-fibrotic versus anti-fibrotic features with functional value for human fibrosis. Here we quantified spatiotemporally resolved matrix transformations for integration with multi-omic data.
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Nov 19, 2024 | 
practicesource.com | Howard Chang
Not sure many will be listening!18 Pages Posted: 23 Feb 2024Date Written: February 21, 2024 Keywords: Liberalized immigration, global welfare, immigration policies, welfare of natives, environmental protection, immigrants, labor market. JEL Classification: F22, J38, J60, J61, K37Suggested Citation:Chang, Howard F., The Economic Case for Liberalized Immigration Policies (February 21, 2024).
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Nov 15, 2024 | 
digitalcommons.library.tmc.edu | Ling-Ling Chen |Albrecht Bindereif |Irene Bozzoni |Howard Chang
KeywordsRNA, Circular, Eukaryota, RNA, Eukaryotic Cells, Alternative splicing, back-splicing, back-splice junction, circRNA, ciRNA, nomenclatureAbstractAlternative splicing of eukaryotic transcripts often leads to production of multiple mature RNAs from a single gene locus.
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Nov 6, 2024 | 
nature.com | Oriol Pich |Kerstin Thol |Jens Luebeck |Natasha E. Weiser |Wei-Ting Lu |Brooke E. Howitt | +11 more
AbstractExtrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer1,2. Here we examine the diversity of ecDNA elements across cancer, revealing the associated tissue, genetic and mutational contexts. By analysing data from 14,778 patients with 39 tumour types from the 100,000 Genomes Project, we demonstrate that 17.1% of tumour samples contain ecDNA.
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Oct 10, 2024 | 
medrxiv.org | Linzi Li |Wenhao Wang |Howard Chang |Alvaro Alonso |Álvaro Alonso
The authors have declared no competing interest. This work was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number 1R01ES032140 (Liu) and R01ES027892 (Chang), and the American Heart Association under Award Number 23PRE1020888 (Li). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Aug 2, 2024 | 
mdpi.com | Howard Chang |Niamh Malhotra |Nikita Kasaraneni |Zoya Ahadian
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jul 26, 2024 | 
newsdata.com | Howard Chang
Pacific Gas & Electric has grabbed headlines in recent months for the huge rate increases that it claims are needed to pay for safety improvements to its system. Those increases are affecting Ava Community Energy customers, who pay Ava for electricity and pay PG&E to have it delivered. In fact, Ava customers pay twice as much to PG&E to have power delivered as they do for the electricity itself.
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Jul 26, 2024 | 
newsdata.com | Howard Chang
Pacific Gas & Electric has grabbed headlines in recent months for the huge rate increases that it claims are needed to pay for safety improvements to its system. Those increases are affecting Ava Community Energy customers, who pay Ava for electricity and pay PG&E to have it delivered. In fact, Ava customers pay twice as much to PG&E to have power delivered as they do for the electricity itself.
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Jul 24, 2024 | 
nature.com | Vincent van Unen |Steven M. Chirieleison |Joshua Chan |Kathryn E Yost |Zachary M. Sellers |Howard Chang | +5 more
AbstractIn vitro models of autoimmunity are constrained by an inability to culture affected epithelium alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is an autoimmune disease in which dietary gluten-derived peptides bind to the major histocompatibility complex (MHC) class II human leukocyte antigen molecules (HLA)-DQ2 or HLA-DQ8 to initiate immune-mediated duodenal mucosal injury1,2,3,4.
