Ling Wang

4 weeks ago | biorxiv.org | Michael Cohen |Madison Bailey |Ling Wang |Erika Smith-Mahoney

AbstractUnraveling biological complexity, whether it be immune subset distribution in infectious disease(s), autoimmunity or tumor heterogeneity, requires technologies capable of single-cell proteomic analysis, such as flow cytometry. Surface immunophenotyping alone is often insufficient, as interrogating functional capacity is required to determine cellular mechanisms and effectively inform diagnostic biomarker discovery, therapeutics and vaccine development.

2 months ago | nature.com | Ling Wang |Elizabeth Wasilevich |Jennifer Gray |Kerri Smith |Jordan M. Bailey |Taylor S. Noyes | +4 more

Per- and polyfluoroalkyl substances (PFAS) may disrupt thyroid hormones although the literature shows mixed evidence of this effect and exposure to mixtures of PFAS remains poorly understood. We used the Michigan PFAS Exposure and Health Study cohort to examine linear and nonlinear associations between serum PFAS concentrations, both alone and as a mixture, and serum thyroid hormone concentrations. Study participants included 728 adolescents and adults living in an area with past PFAS contamination of drinking water. We quantified 39 individual PFAS and four thyroid hormones in serum from participants between the years 2020 and 2021. Linear regression, weighted quantile sum (WQS) regression, supervised Principal Component Analysis (PCA), and Bayesian Kernel Machine Regression (BKMR) were used. When analyzed individually, a 1% increase in PFUnA serum concentrations was associated with a 0.023% decrease in TT3 concentration (95% CI: -0.04%, -0.01%, p < 0.05). All three mixture analyses consistently indicated an inverse relationship between PFAS mixtures and TT3 concentrations: (1) a one standard deviation increase in the WQS of the PFAS mixture was associated with a 2.0% decrease in TT3 concentration (95% CI= -4%, 0%, p < 0.05) adjusting for covariates, (2) using PCA, one standard deviation increase in a PFAS mixture was associated with a 1.2% decrease in TT3 (95% CI: -2.1%, -0.4%), and (3) BKMR similarly suggested a negative association between the PFAS mixture and TT3. We observed cross-sectional associations between a mixture of serum PFAS concentrations and thyroid hormone dysregulation, largely manifesting as decreased TT3 serum concentrations.

Feb 17, 2025 | storagenewsletter.com | Ling Wang |Francis Pelletier

By Ling Wang, senior product marketing manager, storage and cloud data services, HPEBuilt on HPE Alletra Storage MP B10000 with a cloud-like experience, the solution delivers data security, scalability, and HA without internet connectivity. Disconnect in connected worldIf you’re in an industry with stringent requirements for data security and compliance – such as defense, healthcare, or finance – you’re likely familiar with the complexities of managing data in highly regulated environments.

Jan 18, 2025 | cool-style.com.tw | Ling Wang

冷氣團來襲，氣溫有感下降，穿什麼鞋子才能時髦又保暖？韓妞最愛、時尚部落客人腳一雙的「雪靴拖鞋（雪靴穆勒鞋）」正是最佳解！今番編輯來餵你解析雪靴拖鞋從被嘲「醜俗」到蛻變為 2025 秋冬必備神器的原因，並整理雪靴拖鞋的 3 大穿搭技巧，以及Blackpink Jennie、Jisoo、Rosé、Lisa 和 Aespa Karina、Giselle 等懂穿韓星的雪靴拖鞋造型範本，想穿出大長腿展現時髦風格，就要這樣穿！ 延伸閱讀：韓妞瘋這些！GD品牌聯名小貓玩偶、Y2K風格唇頰霜BRAYE、《魷魚遊戲2》元志安新代言彩妝品牌！ Image via IG:@jennierubyjane/ @sooyaaa__/ @roses_are_rosie/ @lalalalisa_m/ @katarinabluu/ @aerichandesu Image via IG:@ugg...

Jan 17, 2025 | onlinelibrary.wiley.com | Xin Chen |Pediatric Diseases |Ling Wang |Hong Luo Luo

Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.