Linhua Tai

Aug 6, 2024 | biorxiv.org | Yun Zhu |Guoliang Yin |Linhua Tai |Binbin Wang

AbstractIn motile cilia or flagella, the axoneme typically exhibits a "9+2" configuration, with the central apparatus (CA) consisting of extensively modified microtubules C1 and C2 to regulate ciliary motility. How C1 and C2 are interconnected asymmetrically remains unknown due to the lack of complete structural model of CA.

Jan 8, 2024 | nature.com | Linhua Tai

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Nov 20, 2023 | nature.com | Linhua Tai |Fei Sun

AbstractThe propulsion for mammalian sperm swimming is generated by flagella beating. Microtubule doublets (DMTs) along with microtubule inner proteins (MIPs) are essential structural blocks of flagella. However, the intricate molecular architecture of intact sperm DMT remains elusive. Here, by in situ cryo-electron tomography, we solved the in-cell structure of mouse sperm DMT at 4.5–7.5 Å resolutions, and built its model with 36 kinds of MIPs in 48 nm periodicity.

May 31, 2023 | biorxiv.org | Linhua Tai |Xiaojun Huang |Yun Zhu |Guoliang Yin

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