Linlin Li

2 months ago | nature.com | Zhirong Liu |Chuyu Tang |Nannan Han |Zhuoheng Jiang |Shaobo Wang |Quanhong Hu | +7 more

Patients suffering from coronary artery disease (CAD) or peripheral arterial disease (PAD) can benefit from bypass graft surgery. For this surgery, arterial vascular grafts have become promising alternatives when autologous grafts are inaccessible but suffer from numerous postimplantation challenges, particularly delayed endothelialization, intimal hyperplasia, high risk of thrombogenicity and restenosis, and difficulty in timely detection of these subtle pathological changes. We present an electronic vascular conduit that integrates flexible electronics into bionic vascular grafts for in situ, real-time and long-term monitoring for hemadostenosis and thrombosis concurrent with postoperative vascular repair. Following bypass surgery, the integrated bioelectronic sensor based on the triboelectric effect enables monitoring of the blood flow in the vascular graft and identification of lesions in real time for up to three months. In male nonhuman primate cynomolgus monkeys, the electronic vascular conduit, with an integrated wireless signal transmission module, enables wireless and real-time hemodynamic monitoring and timely identification of thrombi. This electronic vascular conduit demonstrates potential as a treatment-monitoring platform, providing a sensitive and intuitive monitoring technique during the critical period after bypass surgery in patients with CAD and PAD. Arterial vascular grafts are promising for vascular reconstruction but face risk of restenosis. Here, the authors report an electronic vascular conduit for in situ, long-term monitoring of thrombosis concurrent with postoperative vascular repair in in small animals and nonhuman primates.

Jan 10, 2025 | dx.doi.org | Wenbin Jin |Linlin Li |Yang Luo |JinPing Qiao

Jan 10, 2025 | pubs.acs.org | Wenbin Jin |Linlin Li |Yang Luo |JinPing Qiao

Dec 17, 2024 | pubs.rsc.org | Linlin Li

Versatile hydrogel towards coupling of energy harvesting and storage for self-powered round-the-clock sensing† For realizing intelligent sensing adaptive to various scenarios, flexible and integrated electronics with multiple functions, without sacrifice of electro-chemical properties, are urgently needed.

Sep 16, 2024 | nature.com | Linlin Li

AbstractNanozymes have been attracting widespread interest for the past decade, especially in the field of cancer therapy, due to their intrinsic catalytic activities, strong stability, and ease of synthesis. However, enhancing their catalytic activity in the tumor microenvironment (TME) remains a major challenge.