Quanhong Hu

2 months ago | nature.com | Zhirong Liu |Chuyu Tang |Nannan Han |Zhuoheng Jiang |Shaobo Wang |Quanhong Hu | +7 more

Patients suffering from coronary artery disease (CAD) or peripheral arterial disease (PAD) can benefit from bypass graft surgery. For this surgery, arterial vascular grafts have become promising alternatives when autologous grafts are inaccessible but suffer from numerous postimplantation challenges, particularly delayed endothelialization, intimal hyperplasia, high risk of thrombogenicity and restenosis, and difficulty in timely detection of these subtle pathological changes. We present an electronic vascular conduit that integrates flexible electronics into bionic vascular grafts for in situ, real-time and long-term monitoring for hemadostenosis and thrombosis concurrent with postoperative vascular repair. Following bypass surgery, the integrated bioelectronic sensor based on the triboelectric effect enables monitoring of the blood flow in the vascular graft and identification of lesions in real time for up to three months. In male nonhuman primate cynomolgus monkeys, the electronic vascular conduit, with an integrated wireless signal transmission module, enables wireless and real-time hemodynamic monitoring and timely identification of thrombi. This electronic vascular conduit demonstrates potential as a treatment-monitoring platform, providing a sensitive and intuitive monitoring technique during the critical period after bypass surgery in patients with CAD and PAD. Arterial vascular grafts are promising for vascular reconstruction but face risk of restenosis. Here, the authors report an electronic vascular conduit for in situ, long-term monitoring of thrombosis concurrent with postoperative vascular repair in in small animals and nonhuman primates.

Jan 11, 2025 | onlinelibrary.wiley.com | Zhuo Wang |Nanosystems Chinese Academy |Quanhong Hu |Shuncheng Yao

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202409756-sup-0001-SuppMat.docx3.5 MB Supporting Information References 1, , , , Nat. Rev. Chem. 2021, 5, 773. 2, , , , , , , , , , , , , , , , , , , Nature 2018, 561, 243. 3, , , , , , , , Adv. Sci. 2023, 10, 2301479. 4, , , , , , , , , , , , , , , , , , , , , , Biomaterials 2022, 285, 121479. 5, , , , , , , , , Sci. China Mater. 2023, 66, 3347.