Lisa Ko

Feb 17, 2025 | nature.com | Laura Kellman |Suhas Srinivasan |Margaret Guo |Lisa Ko |Smarajit Mondal |Ibtihal Elfaki | +2 more

AbstractSingle-nucleotide variants (SNVs) in regulatory DNA are linked to inherited cancer risk. Massively parallel reporter assays of 4,041 SNVs linked to 13 neoplasms comprising >90% of human malignancies were performed in pertinent primary human cell types and then integrated with matching chromatin accessibility, DNA looping and expression quantitative trait loci data to nominate 380 potentially regulatory SNVs and their putative target genes.

Jan 6, 2025 | cell.com | Weili Miao |Douglas Porter |Zurab Siprashvili |Ian Ferguson |Luca Ducoli |Duy Nguyen | +11 more

Keywords RNA helicase DDX50 tissue differentiation glucose STAU1 mRNA stability Research topic(s) CP: Molecular biology Introduction RNA-binding proteins (RBPs) can promote either RNA stability or decay to mediate post-transcriptional control of RNA expression in ways important for cell fate.1,2 The DExD/H-box RNA helicases comprise a family of RBPs that exert diverse impacts on RNA, including on RNA translation, folding, and subcellular localization,3 but their impacts on RNA stability are...

Jan 6, 2025 | cell.com | Weili Miao |Douglas Porter |Zurab Siprashvili |Ian Ferguson |Luca Ducoli |Duy Nguyen | +11 more

Keywords RNA helicase DDX50 tissue differentiation glucose STAU1 mRNA stability Research topic(s) CP: Molecular biology Introduction RNA-binding proteins (RBPs) can promote either RNA stability or decay to mediate post-transcriptional control of RNA expression in ways important for cell fate.1,2 The DExD/H-box RNA helicases comprise a family of RBPs that exert diverse impacts on RNA, including on RNA translation, folding, and subcellular localization,3 but their impacts on RNA stability are...

Nov 13, 2024 | time.com | Annabel Gutterman |Lisa Ko

These are independent reviews of the products mentioned, but TIME receives a commission when purchases are made through affiliate links at no additional cost to the purchaser. By Annabel GuttermanNovember 13, 2024 8:03 AM ESTTracing decades of a friendship between three Asian American women—Giselle, Jackie, and Ellen—Lisa Ko’s follow-up to her best-selling 2017 novel The Leavers is an intricate portrait of creativity and ambition.

Oct 26, 2024 | znetwork.org | Lisa Ko

When writer and disability justice activist Alice Wong received a MacArthur Fellowship earlier this month, she shared a statement about accepting it “amidst the genocide happening in Gaza.” The backlash was swift, with a deluge of posts on X attacking Wong’s character and accusing her of antisemitism.