Suhas Srinivasan

Feb 17, 2025 | nature.com | Laura Kellman |Suhas Srinivasan |Margaret Guo |Lisa Ko |Smarajit Mondal |Ibtihal Elfaki | +2 more

AbstractSingle-nucleotide variants (SNVs) in regulatory DNA are linked to inherited cancer risk. Massively parallel reporter assays of 4,041 SNVs linked to 13 neoplasms comprising >90% of human malignancies were performed in pertinent primary human cell types and then integrated with matching chromatin accessibility, DNA looping and expression quantitative trait loci data to nominate 380 potentially regulatory SNVs and their putative target genes.

Jan 6, 2025 | cell.com | Weili Miao |Douglas Porter |Zurab Siprashvili |Ian Ferguson |Luca Ducoli |Duy Nguyen | +11 more

Keywords RNA helicase DDX50 tissue differentiation glucose STAU1 mRNA stability Research topic(s) CP: Molecular biology Introduction RNA-binding proteins (RBPs) can promote either RNA stability or decay to mediate post-transcriptional control of RNA expression in ways important for cell fate.1,2 The DExD/H-box RNA helicases comprise a family of RBPs that exert diverse impacts on RNA, including on RNA translation, folding, and subcellular localization,3 but their impacts on RNA stability are...

Jan 6, 2025 | cell.com | Weili Miao |Douglas Porter |Zurab Siprashvili |Ian Ferguson |Luca Ducoli |Duy Nguyen | +11 more

Keywords RNA helicase DDX50 tissue differentiation glucose STAU1 mRNA stability Research topic(s) CP: Molecular biology Introduction RNA-binding proteins (RBPs) can promote either RNA stability or decay to mediate post-transcriptional control of RNA expression in ways important for cell fate.1,2 The DExD/H-box RNA helicases comprise a family of RBPs that exert diverse impacts on RNA, including on RNA translation, folding, and subcellular localization,3 but their impacts on RNA stability are...