Lisa Reynolds

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A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes - Nature Metabolism

Nov 3, 2024 | nature.com | Patrick Reeson |Jakob Körbelin |Lisa Reynolds

AbstractVascular pathology is associated with cognitive impairment in diseases such as type 1 diabetes; however, how capillary flow is affected and the underlying mechanisms remain elusive. Here we show that capillaries in the diabetic mouse brain in both sexes are prone to stalling, with blocks consisting primarily of erythrocytes in branches off ascending venules. Screening for circulating inflammatory cytokines revealed persistently high levels of interleukin-10 (IL-10) in diabetic mice.

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