Jakob Körbelin

2 months ago | cell.com | Milene Vandal |Adam Institoris |Louise Reveret |Ben Korin |Colin Gunn |Sotaro Hirai | +30 more

KeywordsAlzheimercerebrovascular functionsexual dimorphismbrain endothelial cellsCD2APreelinAβApoER2/LRP8endothelin-1mural cellsGet full text accessLog in, subscribe or purchase for full access. References1. Schaeffer, S. ∙ Iadecola, C. Revisiting the neurovascular unitNat Neurosci. 2021; 24:1198-12092. Korte, N. ∙ Nortley, R. ∙ Attwell, D. Cerebral blood flow decrease as an early pathological mechanism in Alzheimer’s diseaseActa Neuropathol. 2020; 140:793-8103. Yang, A.C. ∙ Vest, R.T. ∙ Kern, F. ...

Nov 28, 2024 | cell.com | Alejandra Raudales |Ben Schager |Dominique Hancock |Sorabh Sharma |Patrick Reeson |Manjinder S. Cheema | +4 more

KeywordsangiogenesismicrocirculationplasticityNotchVEGFrarefactioncapillaryblood flowResearch topic(s)CP: NeuroscienceCP: Molecular biologyIntroductionThe brain uses up to 20% of the energy metabolized by the body to sustain its needs.1 Despite these demands, there is little capacity for energy storage in the form of glycogen; therefore, the brain requires a constant supply of blood.

Nov 3, 2024 | nature.com | Patrick Reeson |Jakob Körbelin |Lisa Reynolds

AbstractVascular pathology is associated with cognitive impairment in diseases such as type 1 diabetes; however, how capillary flow is affected and the underlying mechanisms remain elusive. Here we show that capillaries in the diabetic mouse brain in both sexes are prone to stalling, with blocks consisting primarily of erythrocytes in branches off ascending venules. Screening for circulating inflammatory cytokines revealed persistently high levels of interleukin-10 (IL-10) in diabetic mice.

Mar 21, 2024 | nature.com | Stephan Müller |Jakob Körbelin |Ali Erturk |Dominik Paquet |Stefan F. Lichtenthaler |Katalin Todorov-Völgyi

AbstractAge-related decline in brain endothelial cell (BEC) function contributes critically to neurological disease. Comprehensive atlases of the BEC transcriptome have become available, but results from proteomic profiling are lacking. To gain insights into endothelial pathways affected by aging, we developed a magnetic-activated cell sorting-based mouse BEC enrichment protocol compatible with proteomics and resolved the profiles of protein abundance changes during aging.

Nov 20, 2023 | nature.com | Sarasa Isobe |Rebecca Harper |Jakob Körbelin |Jesse M. Engreitz |Michael Snyder |Shoichiro Otsuki | +2 more

AbstractPulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human PAEC with reduced BMPR2 have persistent DNA damage in room air after hypoxia (reoxygenation), as do mice with EC-specific deletion of Bmpr2 (EC-Bmpr2-/-) and persistent pulmonary hypertension.