Liver Diseases

2 weeks ago | thelancet.com | Brooke E Nichols |Jennifer Dodge |Liver Diseases |Brian Lee

The United States Congress has proposed cuts to Medicaid, reversing the Affordable Care Act expansion.1 These cuts could increase mortality and financial hardship for enrollees while straining health-care providers, especially in rural and underserved areas. Here, we estimate the potential effect on mortality and catastrophic health-care expenditures, defined as out-of-pocket costs exceeding 30% of household income.

4 weeks ago | onlinelibrary.wiley.com | Matthew Wadsworth |David Goldberg |Liver Diseases |Kathryn McGaughey

Data Availability Statement The data that support the findings of this study are available from the Organ Procurement and Transplantation Network (OPTN). Restrictions apply to the availability of these data, which were used under license for this study. Data are available from the author(s) with the permission of the Organ Procurement and Transplantation Network (OPTN).

2 months ago | academic.oup.com | Liver Diseases |David Bergman

Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is an inflammatory condition of the colon, characterized by watery diarrhoea. Previous studies suggest an association between autoimmune thyroid diseases (AITDs) (Hashimoto's thyroiditis and Graves’ disease) and MC; however, large-scale histology studies are lacking. We conducted a nationwide, matched case-control study.

Jan 12, 2025 | ccforum.biomedcentral.com | Liver Diseases

This was a single-center, randomized, double-blind, placebo-controlled, phase 2 trial of inulin for the purpose of preventing gut pathogen colonization and infection in the ICU. Patients were randomized 1:1:1 to placebo, inulin 16 g/day, or inulin 32 g/day beginning on October 14, 2019. Prior to enrollment of the first patient, a data and safety monitoring board (DSMB) was appointed which had full access to the study data.

Dec 10, 2024 | aacrjournals.org | Liver Diseases

Epigenetic clocks can quantify DNA methylation by measuring the methylation levels at specific sites in the genome, which correlate with biological age (BA). Accelerated aging, where BA exceeds chronologic age, has been studied in relation to cancer development, but its utility in cancer prevention remains unclear. Accelerated aging holds promise as a tool to explain the increase in early-onset colorectal cancer (EOCRC).